Fitness analyses of vesicular stomatitis strains with rearranged genomes reveal replicative disadvantages.

@article{Novella2004FitnessAO,
  title={Fitness analyses of vesicular stomatitis strains with rearranged genomes reveal replicative disadvantages.},
  author={Isabel S. Novella and L. Andrew Ball and Gail W. Wertz},
  journal={Journal of virology},
  year={2004},
  volume={78 18},
  pages={9837-41}
}
Gene expression of the nonsegmented negative-strand RNA viruses is determined by the position of each gene relative to that the single 3' promoter. The general order of genes among all of the viruses of the order Mononegavirales is highly conserved. In previous work we generated recombinant viruses in which the order of the three central genes of the prototypical rhabdovirus, vesicular stomatitis virus, was rearranged to all six possible permutations. While some of these viruses replicated less… CONTINUE READING

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Quasispecies and RNA virus evolution: principles and consequences

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