Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

@article{Martnez1991FitnessAO,
  title={Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.},
  author={Mar{\'i}a {\'A}ngeles Mart{\'i}nez and C Castells Carrillo and Fernando Gonz{\'a}lez-Candelas and A Moya and Esteban Domingo and Francisco Sobrino},
  journal={Journal of virology},
  year={1991},
  volume={65 7},
  pages={3954-7}
}
We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions without reversion of the monoclonal antibody-resistant phenotype. Thus, variants that… CONTINUE READING