• Corpus ID: 86091981

Fitness Landscapes, Adaptation and Sex on the Hypercube

  title={Fitness Landscapes, Adaptation and Sex on the Hypercube},
  author={Johannes Neidhart},
The focus of this thesis is on the theoretical treatment of fitness landscapes in the context of evolutionary processes. Fitness landscapes connect an organism’s genome to its fitness. They are an important tool of theoretical evolutionary biology and in the recent years also experimental results became available. In this thesis, several models of fitness landscapes are analyzed with different analytical and numerical methods. The goal is to identify characteristics in order to compare the… 
Greedy adaptive walks on a correlated fitness landscape.
RMF accessibility percolation on oriented graphs
Values of c are determined for having RMF accessibility percolation on four families of graphs: the hypercube, the n-ary trees, the regular trees, and the two-dimensional lattices L and Lalt.
Properties of Random Fitness Landscapes and Their Influence on Evolutionary Dynamics. A Journey through the Hypercube
The individual-based Wright-Fisher model is used to study recombination of genotypes, interactions between individuals and the influence of the underlying fitness landscape on these mechanisms.


Empirical fitness landscapes and the predictability of evolution
This work reviews recent empirical and theoretical developments of the genotype–fitness map, identifies methodological issues and organizing principles, and discusses possibilities to develop more realistic fitness landscape models.
Statistical topography of fitness landscapes
Fitness landscapes are generalized energy landscapes that play an important conceptual role in evolutionary biology. These landscapes provide a relation between the genetic configuration of an
Evolutionary Accessibility in Tunably Rugged Fitness Landscapes
Some measures of accessibility behave non-monotonically as a function of K, indicating a special role of the most sparsely connected, non-trivial cases K=1 and 2, and the relation between models for fitness landscapes and spin glasses is addressed.
Evolutionary Accessibility of Modular Fitness Landscapes
The block model can be viewed as a special case of Kauffman’s NK-model, and it is shown that the number of accessible paths can be written as a product of the path numbers within the blocks, which provides a detailed analytic description of the paths statistics.
Adaptation in Tunably Rugged Fitness Landscapes: The Rough Mount Fuji Model
A simple fitness landscape model with tunable ruggedness based on the rough Mount Fuji (RMF) model originally introduced by Aita et al. in the context of protein evolution is proposed and compared to the known behavior in the MLM model.
The Effect of Bacterial Recombination on Adaptation on Fitness Landscapes with Limited Peak Accessibility
It is concluded that recombination has complex effects on adaptation that are highly dependent on the particular fitness landscape, population size and recombination rate.
Quantitative analyses of empirical fitness landscapes
The aim of this review is to identify measures of epistasis that allow a meaningful comparison of fitness landscapes and then apply them to the empirical landscapes to discern factors that affect ruggedness.
Predicting the Evolution of Sex on Complex Fitness Landscapes
The difficulty of establishing reliable criteria for the evolution of sex on complex fitness landscapes is highlighted and illustrates the challenge for both theoretical and experimental research on the origin and maintenance of sexual reproduction.
Kauffman and Levin introduced a class of models for the evolution of hereditary systems which they called NK fitness landscapes. Inspired by spinglasses, these models have the attractive feature of