Fitness Effects of Cis-Regulatory Variants in the Saccharomyces cerevisiae TDH3 Promoter.

@article{Duveau2017FitnessEO,
  title={Fitness Effects of Cis-Regulatory Variants in the Saccharomyces cerevisiae TDH3 Promoter.},
  author={Fabien Duveau and William Toubiana and Patricia J. Wittkopp},
  journal={Molecular biology and evolution},
  year={2017},
  volume={34 11},
  pages={2908-2912}
}
Variation in gene expression is widespread within and between species, but fitness consequences of this variation are generally unknown. Here, we use mutations in the Saccharomyces cerevisiae TDH3 promoter to assess how changes in TDH3 expression affect cell growth. From these data, we predict the fitness consequences of de novo mutations and natural… CONTINUE READING