Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

@article{Featherstone1991FissionYP,
  title={Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase},
  author={Carol Featherstone and Paul Russell},
  journal={Nature},
  year={1991},
  volume={349},
  pages={808-811}
}
THE fission yeast wee1+ gene product is a dose-dependent, negative regulator of entry into mitosis1,2. wee1+ encodes a protein of relative molecular mass 107,000 (Mr 107K), the C-terminal third of which has strong similarities with the serine/threonine protein kinase family2,3. Here we report that p107wee1 immune complexes phosphorylate p107wee1 equally on serine and tyrosine residues, and also phosphorylate an exogenous substrate, angiotensin II, on tyrosine. Both kinase activities are… CONTINUE READING
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