Fission yeast mating-type switching: programmed damage and repair.

@article{Egel2005FissionYM,
  title={Fission yeast mating-type switching: programmed damage and repair.},
  author={Richard Egel},
  journal={DNA repair},
  year={2005},
  volume={4 5},
  pages={525-36}
}
Mating-type switching in fission yeast follows similar rules as in budding yeast, but the underlying mechanisms are entirely different. Whilst the initiating double-strand cut in Saccharomyces cerevisiae requires recombinational repair for survival, the initial damage in Schizosaccharomyces pombe only affects a single strand, which can be sealed by gap repair in situ, whether or not it serves as an imprint for subsequent switching of mating type from an appropriate donor cassette. Recent papers… CONTINUE READING

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