Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.

@article{Saka1994FissionYC,
  title={Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.},
  author={Yasushi Saka and Takashi Sutani and Yoriaki Yamashita and Shigeaki Saitoh and Masao Takeuchi and Yukinobu Nakaseko and Mitsuhiro Yanagida},
  journal={The EMBO journal},
  year={1994},
  volume={13 20},
  pages={
          4938-52
        }
}
Fission yeast temperature-sensitive mutants cut3-477 and cut14-208 fail to condense chromosomes but small portions of the chromosomes can separate along the spindle during mitosis, producing phi-shaped chromosomes. Septation and cell division occur in the absence of normal nuclear division, causing the cut phenotype. Fluorescence in situ hybridization demonstrated that the contraction of the chromosome arm during mitosis was defective. Mutant chromosomes are apparently not rigid enough to be… CONTINUE READING
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