Fission yeast chromatin assembly factor 1 assists in the replication-coupled maintenance of heterochromatin.

@article{Dohke2008FissionYC,
  title={Fission yeast chromatin assembly factor 1 assists in the replication-coupled maintenance of heterochromatin.},
  author={Kohei Dohke and Shota Miyazaki and Katsunori Tanaka and Takeshi Urano and Shiv I S Grewal and Yota Murakami},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2008},
  volume={13 10},
  pages={1027-43}
}
Chromatin assembly factor-1 (CAF1) is a well-conserved histone chaperone that loads the histone H3-H4 complex onto newly synthesized DNA in vitro through interaction with the replication factor PCNA. CAF1 is considered to be involved in heterochromatin maintenance in several organisms, but the evidence is circumstantial and functional details have not been… CONTINUE READING