Fission yeast Rnf4 homologs are required for DNA repair.

  title={Fission yeast Rnf4 homologs are required for DNA repair.},
  author={Ana Kosoy and Teresa M. Calonge and Emily A Outwin and Matthew J O'Connell},
  journal={The Journal of biological chemistry},
  volume={282 28},
We describe two RING finger proteins in the fission yeast Schizosaccharomyces pombe, Rfp1 and Rfp2. We show that these proteins function redundantly in DNA repair. Rfp1 was isolated as a Chk1-interacting protein in a two-hybrid screen and has high amino acid sequence similarity to Rfp2. Deletion of either gene does not cause a phenotype, but a double deletion (rfp1Deltarfp2Delta) showed poor viability and defects in cell cycle progression. These cells are also sensitive to DNA-damaging agents… CONTINUE READING