Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.

@article{Hirata2002FissionYM,
  title={Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.},
  author={D. B. Hirata and Norihito Kishimoto and Masako Suda and Yuki Sogabe and Sayuri Nakagawa and Yasuko Yoshida and Keisuke Sakai and Masaki Mizunuma and Tokichi Miyakawa and Junpei Ishiguro and Takashi Toda},
  journal={The EMBO journal},
  year={2002},
  volume={21 18},
  pages={4863-74}
}
Fission yeast cells identify growing regions at the opposite ends of the cell, producing the rod-like shape. The positioning of the growth zone(s) and the polarized growth require CLIP170-like protein Tip1 and the Ndr kinase Orb6, respectively. Here, we show that the mor2/cps12 mutation disrupts the localization of F-actin at the cell ends, producing spherical cells and concomitantly inducing a G(2) delay at 36 degrees C. Mor2 is important for the localization of F-actin at the cell end(s) but… CONTINUE READING