Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.

Abstract

Accumulation of depolarized mitochondria within beta-cells has been associated with oxidative damage and development of diabetes. To determine the source and fate of depolarized mitochondria, individual mitochondria were photolabeled and tracked through fusion and fission. Mitochondria were found to go through frequent cycles of fusion and fission in a… (More)
DOI: 10.1038/sj.emboj.7601963

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Cite this paper

@article{Twig2008FissionAS, title={Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.}, author={Gilad Twig and Alvaro A. Elorza and Anthony J A Molina and Hibo Mohamed and Jakob D Wikstrom and Gil Walzer and Linsey Stiles and Sarah E. Haigh and Steve Katz and Guy Las and Joseph Alroy and Min Wu and B{\'e}n{\'e}dicte F Py and Junying Yuan and Jude T. Deeney and Barbara E Corkey and Orian S Shirihai}, journal={The EMBO journal}, year={2008}, volume={27 2}, pages={433-46} }