Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment

@inproceedings{Moser2009FissionYT,
  title={Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment},
  author={Bettina A Moser and Lakxmi Subramanian and Lyne Khair and Ya-Ting Chang and Toru M Nakamura},
  booktitle={PLoS genetics},
  year={2009}
}
The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts, Arabidopsis, Drosophila, and mammals. However, the molecular basis for telomere instability in cells lacking ATM and ATR has not yet been elucidated fully in organisms that utilize both the telomere protection complex shelterin and telomerase to maintain telomeres, such as fission yeast and humans. Here, we demonstrate by quantitative… CONTINUE READING

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