Fisher syndrome: clinical features, immunopathogenesis and management

@article{Mori2012FisherSC,
  title={Fisher syndrome: clinical features, immunopathogenesis and management},
  author={Masahiro Mori and S. Kuwabara and Nobuhiro Yuki},
  journal={Expert Review of Neurotherapeutics},
  year={2012},
  volume={12},
  pages={39 - 51}
}
Since Miller Fisher’s first report in 1956, evidence has accumulated about clinical and laboratory features, immunopathogenesis and treatment of Fisher syndrome (FS). Our literature review revealed the nature of FS. It has relatively uniform clinical and laboratory features. Ophthalmoplegia, ataxia and areflexia are essential prerequisites for an FS diagnosis, but there are several clinical variants with isolated ophthalmoplegia or ataxia. The discovery of serum anti-GQ1b antibody in FS has led… 
Ophthalmoplegia Due to Miller Fisher Syndrome in a Patient With Myasthenia Gravis
TLDR
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TLDR
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TLDR
No early predictors for progression from MFS to MFS‐GBS overlap syndrome were found and all transitions occurred in the first week, implicates that all patients with MFS need careful monitoring for at least 1 week.
An Adult Case of Fisher Syndrome Subsequent to Mycoplasma pneumoniae Infection
TLDR
A 38-yr-old man who had been treated with antibiotics for serologically proven M. pneumoniae pneumonia presented with a sudden onset of diplopia, ataxic gait, and areflexia, and detection of serum anti-ganglioside GQ1b antibody titers led to the diagnosis of Fisher syndrome.
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TLDR
Signs and signs are similar but electrophysiological and lab parameters could be more affected in recurrent episodes, generally there is a prolonged period of time between episodes.
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A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?
TLDR
The case of a 32-year-old Hispanic male who presented with acute, severe thromboembolic disease and concurrently demonstrated characteristic clinical features of Miller Fisher Syndrome including ophthalmoplegia, ataxia, and areflexia is reported.
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References

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Plasmapheresis and Miller Fisher syndrome: analysis of 50 consecutive cases
TLDR
A retrospective analysis of 50 consecutive patients with MFS to clarify whether plasmapheresis enhanced the speed of recovery and to compare its clinical effects in patients treated and not treated with plasmAPheresis.
Anti-GQ 1 b IgG antibody syndrome : clinical and immunological range
We read with interest the article by Odaka et al. In this article, the authors attempted to establish a nosological relation between Miller Fisher syndrome, Guillain-Barré syndrome with
THE MILLER FISHER SYNDROME
INTRODUCTION Although variants of the Guilllan-Barre' syndrome (GBS) with ataxia, areflexia, and ophthalmoplegia were reported prior to 1956, Fisher, first described three cases with this distinct
Syndrome of external ophthalmoplegia, ataxia, and areflexia (Fisher); ocular manifestations in acute idiopathic polyneuritis (Guillain-Barré syndrome); report of two cases.
TLDR
It is thought that individual instances belonging to this group merit description, and two such cases are here presented.
How do we identify infectious agents that trigger Guillain–Barré syndrome, Fisher syndrome and Bickerstaff brainstem encephalitis?
TLDR
The condition is now referred to asMiller Fisher syndrome or Fisher syndrome (FS), the latter nomenclature to avoid any misconceptions that Miller and Fisher are two separate persons.
Fisher syndrome and Bickerstaff brainstem encephalitis (Fisher–Bickerstaff syndrome)
  • N. Yuki
  • Medicine
    Journal of Neuroimmunology
  • 2009
TLDR
A considerable number of patients with Bickerstaff brainstem encephalitis have associated Guillain-Barré syndrome, indicative that these two disorders are closely related on a continuous spectrum.
Treatment for Fisher syndrome, Bickerstaff's brainstem encephalitis and related disorders.
TLDR
No randomised or non-randomised prospective controlled trials of immunotherapy in Fisher Syndrome or related disorders are found to provide the best available evidence from randomised controlled trials on the role of acute immunomodulatory therapy in the treatment of Fisher Syndrome.
Absence of CNS Lesion in Autopsied Patients With Miller-Fisher Syndrome
TLDR
The ophthalmoplegia and ataxia suggest that there may be immunologic similarities between oculomotor nerves and certain (?spinocerebellar) afferents in peripheral nerves.
Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody
TLDR
Clinical features and patterns of external and internal ophthalmoplegia of AO, and neuro-ophthalmologic findings were compared with those of other anti-GQ1b syndromes with ophthalmology, and found internal ocular involvement is fairly common and unilateral involvement may occur in AO.
The Miller Fisher Syndrome
TLDR
The eponym Miller Fisher syndrome (MFS) was named after Dr. Charles Miller Fisher after he described 3 patients with acute onset of ophthalmoplegia, ataxia and areflexia that followed acute upper respiratory infections in 1956.
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