Fish p53 as a possible biomarker for genotoxins in the aquatic environment.

@article{Bhaskaran1999FishPA,
  title={Fish p53 as a possible biomarker for genotoxins in the aquatic environment.},
  author={Ambily Bhaskaran and David May and Mariann Rand-Weaver and Charles R. Tyler},
  journal={Environmental and molecular mutagenesis},
  year={1999},
  volume={33 3},
  pages={177-84}
}
The p53 gene is a tumour suppressor gene which has a fundamental role in cell cycle control and division, and in mammals certain genotoxic agents induce specific mutations in p53, leading to tumourigenesis. Fish have been investigated as models for studying carcinogens, but as yet very little data exists that links exposure to specific chemicals with the aetiology of tumours found in wild populations. In this study, p53 was sequenced from five species of fish with a view to the possible use of… CONTINUE READING

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