Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge.

@article{Liu2013FishOA,
  title={Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge.},
  author={Y. Liu and Feng Chen and Q. Li and J. Odle and Xi Lin and H. Zhu and D. Pi and Y. Hou and Yu Hong and Haifeng Shi},
  journal={The Journal of nutrition},
  year={2013},
  volume={143 11},
  pages={
          1799-807
        }
}
  • Y. Liu, Feng Chen, +7 authors Haifeng Shi
  • Published 2013
  • Chemistry, Medicine
  • The Journal of nutrition
  • Long-chain n-3 (ω-3) polyunsaturated fatty acids exert beneficial effects in neuroendocrine dysfunctions in animal models and clinical trials. However, the mechanism(s) underlying the beneficial effects remains to be elucidated. We hypothesized that dietary treatment with fish oil (FO) could mitigate LPS-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis through inhibition of Toll-like receptor 4 and nucleotide-binding oligomerization domain protein signaling pathways. Twenty… CONTINUE READING
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