Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge.

@article{Liu2013FishOA,
  title={Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge.},
  author={Y. Liu and Feng Chen and Q. Li and J. Odle and Xi Lin and H. Zhu and D. Pi and Y. Hou and Yu Hong and Haifeng Shi},
  journal={The Journal of nutrition},
  year={2013},
  volume={143 11},
  pages={
          1799-807
        }
}
  • Y. Liu, Feng Chen, +7 authors Haifeng Shi
  • Published 2013
  • Chemistry, Medicine
  • The Journal of nutrition
    • Long-chain n-3 (ω-3) polyunsaturated fatty acids exert beneficial effects in neuroendocrine dysfunctions in animal models and clinical trials. However, the mechanism(s) underlying the beneficial effects remains to be elucidated. We hypothesized that dietary treatment with fish oil (FO) could mitigate LPS-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis through inhibition of Toll-like receptor 4 and nucleotide-binding oligomerization domain protein signaling pathways. Twenty… CONTINUE READING
    View PDF
    20 Citations
    Highly Influential Citations
    1
    Background Citations
    9
    Methods Citations
    3
    20 Citations
    Citation Type

    Citation Type

    Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge
    • 12
    • PDF
    Effect of lipopolysaccharide-induced immune stimulation and maternal fish oil and microalgae supplementation during late pregnancy on nursery pig hypothalamic-pituitary-adrenal function.
    • 4
    DHA reduces hypothalamic inflammation and improves central leptin signaling in mice.
    • 1
    Prostaglandins and n-3 polyunsaturated fatty acids in the regulation of the hypothalamic-pituitary axis.
    • B. Shewchuk
    • Biology, Medicine
    • Prostaglandins, leukotrienes, and essential fatty acids
    • 2014
    • 14
    Dietary ω-3 fatty acids and their influence on inflammation via Toll-like receptor pathways.
    High Fat Diet Dysregulates Hypothalamic‐Pituitary Axis Gene Expression Levels which are Differentially Rescued by EPA and DHA Ethyl Esters
    The protective effect of omega-3 fatty acids on cardiac injury in lipopolysaccharide-induced acute sepsis rats model
    • PDF
    Effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation to lactating sows on growth and indicators of stress in the post-weaned pig.
    • 3
    • PDF
    Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway
    • 8
    Microalgae supplementation to late gestation sows and its effects on the health status of weaned piglets fed diets containing high- or low-quality protein sources.
    • 2

    References

    SHOWING 1-10 OF 51 REFERENCES
    Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge.
    • 151
    • PDF
    Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.
    • 44
    • PDF
    Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge.
    • 70
    Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers.
    • 70
    • PDF
    Up-regulated expression of peroxisome proliferator-activated receptor gamma in the hypothalamic-pituitary-adrenal axis of weaned pigs after Escherichia coli lipopolysaccharide challenge.
    • 12
    Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection.
    • Y. Liu, J. Lu, +7 authors G. Yi
    • Biology, Medicine
    • Veterinary immunology and immunopathology
    • 2008
    • 29
    Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge.
    • 28
    Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids
    • 153
    • PDF
    Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
    • 95
    • PDF
    Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium.
    • 83