Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1.

@article{Morimoto1994FishOA,
  title={Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1.},
  author={Masafumi Morimoto and Mark A. Zern and A L Hagbj{\"o}rk and Magnus Ingelman-Sundberg and Samuel William French},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1994},
  volume={207 2},
  pages={197-205}
}
Rats were fed ethanol in combination with fish oil or a corn diet in order to evaluate the effect of fish oil feeding on liver injury, microsomal ethanol oxidation, and NADPH-dependent lipid peroxidation. The rats were maintained on the dietary regimen for 72 days, and for comparison, pair-fed controls were studied. The liver pathology score progressively worsened in rats fed alcohol, both in combination with fish oil and corn oil, but the severity of inflammation and focal fibrosis was greater… CONTINUE READING

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