Fish macrophages express a cyclo-oxygenase-2 homologue after activation.

  title={Fish macrophages express a cyclo-oxygenase-2 homologue after activation.},
  author={Jun Zou and Norman F. Neumann and Jason W. Holland and Miodrag Mike Belosevic and Charles Cunningham and Christopher J Secombes and Andrew F. Rowley},
  journal={The Biochemical journal},
  volume={340 ( Pt 1)},
In mammals, the increased generation of prostaglandins (PG) during the onset of inflammatory responses and activation of immune cell types has been attributed to the induction of a novel cyclo-oxygenase (COX) isoform, termed COX-2, which is distinct from the well-characterized constitutive activity (COX-1). Goldfish (Carassius auratus) macrophages exposed to bacterial lipopolysaccharide and leucocyte-derived macrophage-activating factor(s) showed a significant increase in the generation of the… CONTINUE READING
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