Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells.

@article{Diaz2007FishGT,
  title={Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells.},
  author={M{\^o}nica Taiane de Mac{\^e}do Diaz and Costin N Antonescu and Encarnaci{\'o}n Capilla and Amira Klip and Josep V Planas},
  journal={Endocrinology},
  year={2007},
  volume={148 11},
  pages={5248-57}
}
In mammals, glucose transporter (GLUT)-4 plays an important role in glucose homeostasis mediating insulin action to increase glucose uptake in insulin-responsive tissues. In the basal state, GLUT4 is located in intracellular compartments and upon insulin stimulation is recruited to the plasma membrane, allowing glucose entry into the cell. Compared with mammals, fish are less efficient restoring plasma glucose after dietary or exogenous glucose administration. Recently our group cloned a GLUT4… CONTINUE READING
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