Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.
@article{KrisEtherton2002FishCF, title={Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.}, author={Penny M. Kris-Etherton and William S. Harris and Lawrence J. Appel}, journal={Arteriosclerosis, thrombosis, and vascular biology}, year={2002}, volume={23 2}, pages={ e20-30 } }
fatty acids affect cardiac function (including antiarrhythmic effects), hemodynamics (cardiac mechanics), and arterial endothelial function have helped clarify potential mechanisms of action. The present Statement will address distinctions between plant-derived (-linolenic acid, C18:3n-3) and marine-derived (eicosapentaenoic acid, C20:5n-3 [EPA] and docosahexaenoic acid, C22:6n-3 [DHA]) omega-3 fatty acids. (Unless otherwise noted, the term omega-3 fatty acids will refer to the latter…Â
3,018 Citations
Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.
- MedicineCirculation
- 2002
Recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation in the context of recent guidance issued by the US Environmental Protection Agency and the Food and Drug Administration about the presence of environmental contaminants in certain species of fish.
Reprint of: Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease.
- MedicineFitoterapia
- 2018
Omega-3 fatty acids from fish oils and cardiovascular disease.
- Medicine, BiologyMolecular and cellular biochemistry
- 2004
Control intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death.
Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives.
- MedicineAtherosclerosis
- 2008
Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins
- BiologyEuropean Journal of Clinical Nutrition
- 2013
The focus here will be the plasma lipid modulatory effects of EPA and DHA and will include an exploration of the potential and demonstrated complementarity between statins and EPA/DHA on overall CVD risk and the plasma cholesterol and triglyceride profile.
Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020
- Biology, MedicineInternational journal of molecular sciences
- 2020
This review presents some of the key studies that have investigated EPA and DHA in the primary and secondary prevention of CVD, describes potential mechanisms for their cardioprotective effect, and evaluates the more recently published RCTs in the context of existing scientific literature.
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
- MedicineThe Cochrane database of systematic reviews
- 2020
BACKGROUND
Omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3)), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants…
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
- MedicineThe Cochrane database of systematic reviews
- 2018
Effect of increased intake of fish- and plant-based omega-3 for all-cause mortality, cardiovascular (CVD) events, adiposity and lipids is assessed and it is suggested that LCn3 probably makes little or no difference to CHD event risk.
Omega-3 fatty acids and cytochrome P450-derived eicosanoids in cardiovascular diseases: Which actions and interactions modulate hemodynamics?
- BiologyProstaglandins & other lipid mediators
- 2017
References
SHOWING 1-10 OF 151 REFERENCES
n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans.
- MedicineThe American journal of clinical nutrition
- 1997
Findings suggest that FOC supplementation may stimulate systemic nitric oxide synthesis and suggest another mechanism whereby n-3 fatty acids may be antiatherogenic.
Dietary fish oil (4 g daily) and cardiovascular risk markers in healthy men.
- MedicineArteriosclerosis, thrombosis, and vascular biology
- 1997
It is indicated that lowering of postprandial triglycerides is the only n-3 VLCPUFA effect that could contribute to primary prevention of IHD in healthy middle-aged men as assessed by currently measurable lipid and hemostatic risk markers.
Essential fatty acids as determinants of lipid requirements in infants, children and adults
- MedicineEuropean Journal of Clinical Nutrition
- 1999
Results from human infant studies suggest that n-3 fatty acids are needed for optimal development of visual and brain function, and human milk is the best and only time proven source of fat and dietary essential fatty acids for infant feeding.
The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial.
- MedicineAnnals of internal medicine
- 1999
Dietary intake of omega-3 fatty acids modestly mitigates the course of coronary atherosclerosis in humans.
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
- MedicineThe Lancet
- 1999
Association of dietary fish and n-3 fatty acid intake with hemostatic factors in the coronary artery risk development in young adults (CARDIA) study.
- MedicineArteriosclerosis, thrombosis, and vascular biology
- 1998
The data suggest that customary intakes of fish and n-3 fatty acids in populations that generally do not consume large amounts of these food items are not associated with these hemostatic factors.
Polyunsaturated fatty acids in the food chain in the United States.
- Environmental ScienceThe American journal of clinical nutrition
- 2000
Alternative strategies, such as food enrichment and the use of biotechnology to manipulate the EPA and DHA as well as ALA contents of the food supply, will become increasingly important in increasing n-3 fatty acid intake in the US population.
The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease.
- Medicine, BiologyArteriosclerosis, thrombosis, and vascular biology
- 1999
The results indicate that n-3 FA supplementation decreases hemostatic markers of atherosclerosis, whereas markers of inflammation may be increased.
Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants.
- ChemistryArteriosclerosis, thrombosis, and vascular biology
- 1997
Omega-3 FAs neither rendered the LDL particles more susceptible to undergo in vitro oxidation nor influenced mononuclear cells' ability to oxidize autologous LDL, whereas moderate amounts of antioxidants protected LDL against oxidative modification.
Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: the EURAMIC study.
- MedicineArteriosclerosis, thrombosis, and vascular biology
- 1999
In this large case-control study, there is no evidence of association with risk of myocardial infarction of omega-3 fatty acids in adipose tissue, and the protective effect of alpha-linolenic acid was attenuated after adjusting for classical risk factors, but it deserves further research.