Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7.

@article{Sun2011FishMS,
  title={Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7.},
  author={Fan Ai Qizhen Sun and Yibing Zhang and Ting-Kai Liu and Jun Shi and Bing Wang and Jian-Fang Gui},
  journal={Journal of immunology},
  year={2011},
  volume={187 5},
  pages={2531-9}
}
In mammals, cytosolic sensors retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) activate multiple signaling cascades initiating IFN-α/β expression. IFN regulatory factor 3 (IRF3) is required for the activation of IFN-β, which, in turn, primes the expression of most IFN-α genes by IFN-induced IRF7 through the STAT1 pathway. In fish, RIG-I overexpression inhibits virus infection by induction of IFN response; however, the subtle signaling cascade mechanism remains to be identified. In… CONTINUE READING