Corpus ID: 73687175

Fisetin synergizes with gemcitabine and inhibits viability of MIA PaCa-2 pancreatic cancer cells

@article{Kumar2019FisetinSW,
  title={Fisetin synergizes with gemcitabine and inhibits viability of MIA PaCa-2 pancreatic cancer cells},
  author={B. Kumar},
  journal={The research reports},
  year={2019}
}
  • B. Kumar
  • Published 2019
  • Chemistry
  • The research reports
Gemcitabine (GCB) remains the first line of defense for the treatment of pancreatic cancer. In recent years multiple therapy cycles with GCB have shown a lot of resistance towards pancreatic cancer treatment. Thus different methods have been attempted to improve its potency. This study aims to improve the potency of GCB using dietary molecule Fisetin, a flavonoid molecule commonly found in fruits and vegetables. Pancreatic cancer cell line Mia PaCa-2 was treated with different doses of Fisetin… Expand

Figures and Tables from this paper

References

SHOWING 1-10 OF 15 REFERENCES
Synergistic Combination of Gemcitabine and Dietary Molecule Induces Apoptosis in Pancreatic Cancer Cells and Down Regulates PKM2 Expression
TLDR
The effectiveness of BA or TQ in combination with GCB to inhibit cell proliferation, induce apoptosis and down-regulate the expression of PKM2, reflects promise in pancreatic cancer treatment. Expand
Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line capan-2
TLDR
Signs of an antagonistic interaction between GEM and 5-FU in some pancreatic cancer context urge further investigation of both genetic and non-genetic differences to identify the variables most relevant for optimal selection and dosing of treatment for the individual patient. Expand
Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
TLDR
Investigating whether a naturally occurring diet-based flavonoid, fisetin, could act synergistically with clinically achievable doses of paclitaxel to produce growth inhibitory and/or pro-death effects on A549 non-small cell lung cancer cells concluded that this study is potentially interesting for the development of novel chemotherapeutic approach to non- Small Cell lung cancer. Expand
Fisetin suppresses ADAM9 expression and inhibits invasion of glioma cancer cells through increased phosphorylation of ERK1/2
TLDR
The results suggest that fisetin might be a potential therapeutic agent against human glioma cells based on its capacity to activate ERK1/2 and to inhibit ADAM9 expression. Expand
Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones
TLDR
It is shown that a tumor cell acquired resistance to GEM, and cross-resistance developed in one clone, suggesting that only cells with certain mechanisms for high-level resistance toGEM survive against selective pressure applied by highly concentrated GEM. Expand
Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
TLDR
It is found that combination treatment (fisetin + sorafenib) more effectively reduced the migration and invasion of BRAF-mutated melanoma cells both in vitro and in raft cultures compared to individual agents. Expand
Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention.
TLDR
The results suggest that fisetin inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects, and therefore, f isetin warrants further investigation for its angiopreventive potential toward cancer control. Expand
Gemcitabine resistance in pancreatic ductal adenocarcinoma.
  • Y. Binenbaum, S. Na'ara, Z. Gil
  • Medicine
  • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2015
TLDR
The current knowledge on intrinsic and environment-mediated gem citabine resistance is summarized, and the impact of these pathways on patient screening, and on future treatments aimed to potentiate gemcitabine activity is discussed. Expand
The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms
TLDR
This work examines extrinsic elements to intrinsic processes within the cell that are important for therapeutic efficacy and resistance in PDA cells and discusses resistance mechanisms that will most likely play a role in the management of this deadly disease. Expand
Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts.
TLDR
EGCG at a concentration range of 40-200 microM induced a significant amount of apoptosis in WI38VA cultures, but not inWI38 cultures, as determined by terminal deoxynucleotidyl transferase assay. Expand
...
1
2
...