Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway

@article{Chou2013FisetinIM,
  title={Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway},
  author={Ruey-Hwang Chou and Shu-Ching Hsieh and Yung-Luen Yu and Min-Hsien Huang and Yi-Chang Huang and Y. Hsieh},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
  • Ruey-Hwang Chou, Shu-Ching Hsieh, +3 authors Y. Hsieh
  • Published 2013
  • Medicine, Biology
  • PLoS ONE
  • Fisetin (3,3’,4’,7-tetrahydroxyflavone), a naturally occurring flavonoid, has been reported to inhibit proliferation and induce apoptosis in several cancer types. However, its effect on the anti-metastatic potential of cervical cancer cells remains unclear. In the present study, we found that fisetin inhibits the invasion and migration of cervical cancer cells. The expression and activity of urokinase plasminogen activator (uPA) was significantly suppressed by fisetin in a dose-dependent manner… CONTINUE READING

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