Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects

@article{Cheng2008Fis1DS,
  title={Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects},
  author={W-C Cheng and Xinchen Teng and Hyeong Kyu Park and Cheryl M Tucker and Maitreya J. Dunham and Jonathan Hardwick},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1838-1846}
}
Genetic mutations affecting mitochondrial fission and fusion proteins cause human neurological disorders, but are assumed to be well tolerated in yeast. The conserved mitochondrial fission protein Dnm1/Drp1 is required for normal mitochondrial division, but also promotes cell death in mammals and yeast. Fis1, an outer mitochondrial membrane-anchored receptor for Dnm1/Drp1, also can promote cell death in mammals, but appears to have prosurvival activity in yeast. Here we report that deletion of… CONTINUE READING

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