First trimester serum screening for Down's syndrome.

  title={First trimester serum screening for Down's syndrome.},
  author={Nicholas J Wald and A. Kennard and Allan K Hackshaw},
  journal={Prenatal diagnosis},
  volume={15 13},
Screening for Down's Syndrome has been shown to be effective at 10 weeks of pregnancy. A multicentre study (the first trimester serum screening study) has shown that there are two biochemical markers of choice at this time in pregnancy, namely pregnancy associated placental protein A (PAPP-A) and the free beta-sub-unit of human chorionic gonadotrophin (free beta-hCG). When used together with maternal age these two biochemical markers have an estimated detection rate of 62% and a 5% false… CONTINUE READING
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