First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics.

@article{Kagan2008FirsttrimesterSF,
  title={First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics.},
  author={Karl Oliver Kagan and David Wright and Kevin Sim{\~o}es Spencer and Francisca Sonia Molina and Kypros H. Nicolaides},
  journal={Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology},
  year={2008},
  volume={31 5},
  pages={493-502}
}
OBJECTIVES To use multiple regression analysis to define the contribution of maternal variables that influence the measured concentration of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A), and the interaction between these covariates, in first-trimester biochemical screening for trisomy 21. METHODS This was a multicenter study of prospective screening for trisomy 21 by a combination of fetal nuchal translucency thickness, and maternal… CONTINUE READING
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Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first Copyright  2008 ISUOG

  • K Spencer, V Heath, A El-Sheikhah, CYT Ong, KH. Nicolaides
  • Published by John Wiley & Sons, Ltd. Ultrasound…
  • 2008

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