First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia.

@article{Thadhani2004FirstTP,
  title={First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia.},
  author={Ravi Ishwar Thadhani and Walter P. Mutter and Myles Selig Wolf and Richard LeVine and Robert Norton Taylor and Vikas P Sukhatme and Jeffrey L. Ecker and Siddharth Karumanchi},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 2},
  pages={
          770-5
        }
}
An imbalance of pro- and antiangiogenic factors may lead to preeclampsia (PE). In this prospective nested case-control study, we investigated whether first trimester serum levels of placental growth factor (PlGF), a potent angiogenic factor, and its soluble inhibitor, soluble fms-like tyrosine kinase 1 (sFlt1), distinguished women who developed PE (n = 40) from those who developed gestational hypertension (n = 40), delivered a small for gestational age (SGA) newborn (n = 40), or completed a… CONTINUE READING
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