First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial).

@article{Dugoff2004FirsttrimesterMS,
  title={First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial).},
  author={Lorraine Dugoff and John C. Hobbins and Fergal Desmond Malone and T. Flint Porter and David A. Luthy and Christine H. Comstock and Gary D. V. Hankins and Richard L. Berkowitz and Irwin R. Merkatz and Sabrina Craigo and Ilan E Timor-Tritsch and Stephen R. Carr and Honor M. Wolfe and John Vidaver and Mary E. D'Alton},
  journal={American journal of obstetrics and gynecology},
  year={2004},
  volume={191 4},
  pages={
          1446-51
        }
}
OBJECTIVE The purpose of this study was to determine whether maternal serum levels of pregnancy-associated plasma protein A, free-beta subunit human chorionic gonadotropin, or nuchal translucency size are associated with obstetric complications. STUDY DESIGN Data were obtained from the First and Second Trimester Evaluation of Risk trial. Pregnancy-associated plasma protein A and free-beta subunit human chorionic gonadotropin levels were analyzed, and nuchal translucency was measured between… Expand
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  • S. Soni, D. Krantz, M. Blitz, N. Vohra, B. Rochelson
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
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To study whether low levels of free b-hCG combined to both decreased level PAPP-A MoM and increased nuchal translucency (NT) may be predictive of miscarriage, a large number of women with singleton pregnancies underwent first trimester combined screening. Expand
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References

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Low free β-hCG is associated with a higher incidence of spontaneous miscarriage but is a poor predictor of other pregnancy complications. Expand
Reduced circulating placental protein concentrations during the first trimester are associated with preterm labour and low birth weight.
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Both the gestational age at delivery and low birth weight may be related to impaired placental development/function during the first trimester of pregnancies achieved following in-vitro fertilization and embryo transfer. Expand
Maternal serum levels of free β‐hCG and PAPP‐A in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery
TLDR
It was showed that concentrations of PAPP‐A and free β‐hCG in the first trimester were not associated with subsequent fetal growth retardation or preterm delivery, in contrast with the maternal serum analytes used in second‐trimester screening. Expand
The first trimester ‘combined test’ for the detection of Down syndrome pregnancies in 4939 unselected pregnancies
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The high detection rate (DR) for Down syndrome (DS) pregnancies which can be achieved by measuring fetal nuchal translucency early in pregnancy can be improved by combining it with placental hormones and maternal age and the ‘combined test’ was assessed. Expand
Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth.
TLDR
It is concluded that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregnancy outcome. Expand
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TLDR
A multicenter study of screening for trisomies 21 and 18 among patients with pregnancies between 74 and 97 days of gestation, based on maternal age, maternal levels of free β human chorionic gonadotropin and pregnancy-associated plasma protein A, and ultrasonographic measurement of fetal nuchal translucency identified 85.2 percent of the 61 cases of Down's syndrome. Expand
Association between fetal nuchal translucency thickness in first trimester and subsequent gestational hypertension and preeclampsia
TLDR
It is concluded that the pathological changes in the placenta responsible for the development of PAH may also influence the physiological decrease of NT thickness in late first trimester, however, the sensitivity of fetal NT measurement in firsttrimester is not sufficient as a single marker for predicting the pregnant women at risk for subsequent PAH. Expand
First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications
TLDR
The value of first trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications is examined. Expand
First‐Trimester Sonographic Screening for Down Syndrome
TLDR
An objective assessment of the literature describing nuchal translucency, as well as some adjunct first-trimester sonographic techniques, such as ductus venosus flow and nasal bone studies are provided. Expand
Decreased first trimester PAPP‐A is a predictor of adverse pregnancy outcome
TLDR
Evaluated whether low levels of first trimester PAPP‐A are predictive of other adverse pregnancy outcomes, including spontaneous miscarriage and Down's syndrome. Expand
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