First-trimester maternal plasma cell-free fetal DNA and preeclampsia.

  title={First-trimester maternal plasma cell-free fetal DNA and preeclampsia.},
  author={Stavros K Sifakis and Apostolos Zaravinos and Nerea Maiz and Demetrios A. Spandidos and Kypros H. Nicolaides},
  journal={American journal of obstetrics and gynecology},
  volume={201 5},
OBJECTIVE The purpose of this study was to determine whether, in pregnancies that experience preeclampsia, plasma cell-free fetal DNA (cffDNA) at 11-13 weeks of gestation is increased and whether this increase is related to the uterine artery pulsatility index (PI). STUDY DESIGN Plasma cffDNA and uterine artery PI were measured in 44 cases with preeclampsia, which included 11 cases that required delivery at <34 weeks of gestation and 176 normal control subjects. All fetuses were male, and… CONTINUE READING


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