First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing.

@article{Nicolaides2013FirsttrimesterCS,
  title={First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing.},
  author={Kypros H. Nicolaides and David Wright and Liona Chiu Yee Poon and Argyro Syngelaki and M M Gil},
  journal={Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology},
  year={2013},
  volume={42 1},
  pages={41-50}
}
OBJECTIVE To define risk cut-offs with corresponding detection rates (DR) and false-positive rates (FPR) in screening for trisomy 21 using maternal age and combinations of first-trimester biomarkers in order to determine which women should undergo contingent maternal blood cell-free (cf) DNA testing. METHODS From singleton pregnancies undergoing screening for aneuploidies at three UK hospitals between March 2006 and May 2012, we analyzed prospectively collected data on the following… CONTINUE READING
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