First trimester Down syndrome screening is less effective and the number of invasive procedures is increased in women younger than 35 years of age.

@article{Peuhkurinen2013FirstTD,
  title={First trimester Down syndrome screening is less effective and the number of invasive procedures is increased in women younger than 35 years of age.},
  author={Sini Peuhkurinen and Paivi H Laitinen and Markku Ryynanen and Jaana Marttala},
  journal={Journal of evaluation in clinical practice},
  year={2013},
  volume={19 2},
  pages={324-6}
}
OBJECTIVES We evaluated the performance of first trimester screening for Down syndrome in women less than 35 years of age (study group) and in women aged 35 years or more (control group) in an unselected low-risk population. METHODS The study group comprised a total of 63,945 women who participated in the first trimester combined screening in public health care in Finland during the study period of 1 May 2002 to 31 December 2008. Women at the age of 35 or more (n = 13,004) were controls… CONTINUE READING
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