First total synthesis of (-)- and (+)-6-O-desmethylantofine.

  title={First total synthesis of (-)- and (+)-6-O-desmethylantofine.},
  author={Meng Wu and Ling Li and Bo Su and Zhihui Liu and Qingmin Wang},
  journal={Organic \& biomolecular chemistry},
  volume={9 1},
The first total synthesis of (-)-6-O-desmethylantofine (A) and its unnatural enantiomer (+)-6-O-desmethylantofine (B) is described. The synthetic route is efficient and practical with easily available glutamic acid dimethyl ester hydrochloride as the chiral material under mild conditions. 

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