First results on label-free detection of DNA and protein molecules using a novel integrated sensor technology based on gravimetric detection principles.

@article{Gabl2004FirstRO,
  title={First results on label-free detection of DNA and protein molecules using a novel integrated sensor technology based on gravimetric detection principles.},
  author={Reinhard Gabl and H Feucht and H Zeininger and Gerald Eckstein and Matthias Schreiter and R. Primig and Dana Pitzer and W. Wersing},
  journal={Biosensors & bioelectronics},
  year={2004},
  volume={19 6},
  pages={615-20}
}
A novel integrated bio-sensor technology based on thin-film bulk acoustic wave resonators on silicon is presented and the feasibility of detecting DNA and protein molecules proofed. The detection principle of these sensors is label-free and relies on a resonance frequency shift caused by mass loading of an acoustic resonator, a principle very well known from quartz crystal micro balances. Integrated ZnO bulk acoustic wave resonators with resonance frequencies around 2 GHz have been fabricated… CONTINUE READING
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