First responders: dynamics of pre-gliotic Müller cell responses in the isolated adult rat retina.

  title={First responders: dynamics of pre-gliotic M{\"u}ller cell responses in the isolated adult rat retina.},
  author={Linn{\'e}a Taylor and Karin M Arn{\'e}r and Fredrik Ghosh},
  journal={Current eye research},
  volume={40 12},
PURPOSE To explore the early reactions of the retinal Müller glia in response to retinal insult prior to gliotic remodeling and the sustained upregulation of intermediate filament glial fibrillary acidic protein (GFAP), which has traditionally been considered the most sensitive early indicator of reactive gliosis. METHODS To study pre-gliotic events, we used a model of adult rat retinal explants and related the dynamic expression of GFAP as well as apoptosis, to four key regulators of retinal… CONTINUE READING