First report on fertility after allogeneic uterus transplantation

  title={First report on fertility after allogeneic uterus transplantation},
  author={Cesar Diaz-Garcia and Shamima N. Akhi and Ann Wallin and Antonio Pellicer and Mats Br{\"a}nnstr{\"o}m},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression. 

Uterine transplantation: one human case followed by a decade of experimental research in animal models

The results of these specific studies on surgical technique, ischaemia‐reperfusion injury, immunosuppression and fertility are discussed.

Uterus transplantation: Toward clinical application in Japan

In recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be

Experimental uterus transplantation.

Use of Cyclosporine in Uterine Transplantation

The role of CsA in UTn and its effect on pregnant transplant recipients and their offspring is reviewed and its influence upon the graft during pregnancy is reviewed.

Uterus transplantation and fertility preservation.

Risks for Donors in Uterus Transplantation

The burdens and risks of UTx are summarized, with a focus on donors who provide the uterus, and many medical, ethical, and social problems and risks require discussion prior to widespread clinical application.

Assessment of women who applied for the uterine transplant project as potential candidates for uterus transplantation

To review the medical charts of women who applied for the uterine transplant project from June 2008 to June 2011 in the authors' hospital retrospectively (18–40 years), women's medical charts are reviewed retrospectively.



Pregnancy in recipients of solid organs--effects on mother and child.

The most recent data about the effects on the mother and child of pregnancy in the recipients of solid-organ transplants are discussed.

Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation.

This study demonstrates the feasibility of UTx by vascular anastomosis in a non-human primate species by developing surgical techniques for uterus retrieval and transplantation in the baboon.

Successful uterine transplantation in the mouse: pregnancy and post-natal development of offspring.

These observations document the capacity of a transplanted uterus to harbour pregnancies to term, and reveal that offspring from a transplants uterus develop to normal fertile adults.

Transplantation of the human uterus

  • W. FageehH. RaffaH. JabbadA. Marzouki
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2002

Fertility after autologous ovine uterine-tubal-ovarian transplantation by vascular anastomosis to the external iliac vessels.

This is the first report to demonstrate fertility and pregnancies going to term after autotransplantation of the uterus in an animal of a comparable size to the human.

Auto‐transplantation of the uterus in the domestic pig (Sus scrofa): Surgical technique and early reperfusion events

Aim:  To develop a method for auto‐transplantation of the uterus in the pig and to evaluate the early reperfusion events after short‐term cold ischemia.

Pelvic vascular prospects for uterine transplantation.

Uterine arteryAnastomosis in the porcine model is feasible with subsequent normal vascular function in pregnancy of the anastomosed vessels with minimal intimal fibrosis across all anastsomotic sites.

Uterus transplantation in the rat: Model development, surgical learning and morphological evaluation of healing

A reproducible model for uterus transplantation in the rat was developed and used in future studies concerning uterine function after allogenic transplantation, and both surgeons gained the necessary microsurgical skills needed to achieve above 70% transplant survival at a similar rate.

Heterotopic Uterus Transplantation in a Swine Model

Findings demonstrate that successful uterus transplantation in a large animal model (miniature swine) is feasible using this heterotopic model, and it can be useful for the study of these transplants.

Rejection of allogenic uterus transplant in the mouse: time-dependent and site-specific infiltration of leukocyte subtypes.

Acute rejection of an allogeneic uterus transplant in the mouse involves influx of predominately neutrophils, macrophages, CD8(+) T-cells and CD4(+)T-cells between D2 and D5 post-operatively.