First report on a novel Nigrospora sphaerica isolated from Catharanthus roseus plant with anticarcinogenic properties

@inproceedings{Ayob2017FirstRO,
  title={First report on a novel Nigrospora sphaerica isolated from Catharanthus roseus plant with anticarcinogenic properties},
  author={Farah Wahida Ayob and Khanom Simarani and Nurhayati Zainal Abidin and Jamaludin Mohamad},
  booktitle={Microbial biotechnology},
  year={2017}
}
This paper reports on the vinca alkaloid produced by a novel Nigrospora sphaerica isolated from Catharanthus roseus. Through liquid chromatography-mass spectrometry (LCMS), only the crude mycelia extract of this fungus was positive for determination of vinblastine. This vinca alkaloid was then purified by using high-performance liquid chromatography (HPLC) and tested for cytotoxicity activity using MTT assays. The breast cell line cancer (MDA-MB 231) was treated with a purified vinblastine… CONTINUE READING
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