First report of a ranavirus associated with morbidity and mortality in farmed Chinese giant salamanders (Andrias davidianus).

@article{Geng2011FirstRO,
  title={First report of a ranavirus associated with morbidity and mortality in farmed Chinese giant salamanders (Andrias davidianus).},
  author={Yi Geng and K. Y. Wang and Z. Y. Zhou and C W Li and Jun Wang and Min He and Zhong-qiong Yin and Weimin Lai},
  journal={Journal of comparative pathology},
  year={2011},
  volume={145 1},
  pages={
          95-102
        }
}
  • Y. Geng, K. Wang, +5 authors W. Lai
  • Published 1 July 2011
  • Biology, Medicine
  • Journal of comparative pathology
From February to May 2010, an outbreak of disease occurred amongst farmed Chinese giant salamanders (Andrias davidianus) in Hanzhong County, Shanxi Province, China. Clinical signs included anorexia, lethargy, ecchymoses and swollen areas on the head and limbs, and skin ulceration. The aim of this study was to determine the cause of this disease. Necropsy examination revealed subcutaneous and intramuscular oedema, swollen and pale livers with multifocal haemorrhage, swollen kidneys with… 
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Comparative analysis of the MCP gene sequence with those of other viruses previously isolated from Chinese giant salamanders revealed that these isolates were highly similar, although a few variations were observed.
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The data suggested that the virus isolate was a novel member of the genus Ranavirus, family Iridoviridae, and was able to cause serious systemic disease and it was capable of killing 80% of Chinese giant salamanders.
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Common midwife toad ranaviruses replicate first in the oral cavity of smooth newts (Lissotriton vulgaris) and show distinct strain-associated pathogenicity
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Ranavirus-exposed smooth newts shed virus in feces intermittently and infection was seen in the absence of lesions or clinical signs, indicating that this species can harbor subclinical infections and potentially serve as disease reservoirs.
Ultrastructural morphogenesis of an amphibian iridovirus isolated from Chinese giant salamander (Andrias davidianus).
  • J. Ma, L. Zeng, +5 authors J. Xu
  • Biology, Medicine
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  • 2014
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The EPC cell line represents a suitable in-vitro model for study of GSIV morphogenesis and characterization of the GSIV replication cycle at the ultrastructural level.
Ranavirus (family Iridoviridae ) detection by polymerase chain reaction (PCR) in Chinese giant salamander ( Andrias davidianus , Blanchard, 1871), China
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It is indicated that Ranavirus should be considered a common disease etiology throughout these geographical regions.
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