First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

@inproceedings{Wang2015FirstQH,
  title={First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass},
  author={Guangliang Wang and Surendra Kumar Rajpurohit and Fabien Delaspre and Steven L. Walker and David T White and Alexis M. Ceasrine and Rejji Kuruvilla and Ruo-jing Li and Joong Sup Shim and Jun O Liu and Michael W. Parsons and Jeff S Mumm},
  booktitle={eLife},
  year={2015}
}
Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities possible with in vitro assays. We therefore developed a method enabling in vivo high-throughput screening (HTS) in zebrafish, termed automated reporter quantification in vivo (ARQiv). In this study, ARQiv was combined with robotics to fully actualize whole-organism HTS (ARQiv-HTS). In a primary screen, this platform quantified cell-specific… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS
23 Citations
63 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Optimal high-throughput screening: practical experimental design and data analysis for genomescale RNAi research

  • X. Zhang
  • 2011
Highly Influential
3 Excerpts

A versatile highthroughput whole-organism drug screening platform: ARQiv-HTS

  • DT White, AU Eroglu, +5 authors JS. Mumm
  • Journal of Visualized Experiments
  • 2015
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…