First production of fluorescent anti-ribonucleoproteins conjugate for diagnostic of rabies in Brazil.

@article{Caporale2009FirstPO,
  title={First production of fluorescent anti-ribonucleoproteins conjugate for diagnostic of rabies in Brazil.},
  author={Graciane Maria Medeiros Caporale and Andr{\'e}a de C{\'a}ssia Rodrigues da Silva and Z{\'e}lia Maria Pinheiro Peixoto and Luciana Botelho Chaves and Maria Lu{\'i}za Carrieri and Ruth Camargo Vass{\~a}o},
  journal={Journal of clinical laboratory analysis},
  year={2009},
  volume={23 1},
  pages={7-13}
}
The laboratory tests recommended by the World Health Organization for detection of rabies virus and evaluation of specific antibodies are performed with fluorescent antibodies against the virus, the ribonucleoproteins (RNPs), or by monoclonal antibodies. In this study, we purified the rabies virus RNPs for the production of a conjugate presenting sensibility and specificity compatible with commercial reagents. The method employed for the purification of RNPs was ultracentrifugation in cesium… CONTINUE READING
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