First principles prediction of protein folding rates.

@article{Debe1999FirstPP,
  title={First principles prediction of protein folding rates.},
  author={Derek A. Debe and William A. Goddard},
  journal={Journal of molecular biology},
  year={1999},
  volume={294 3},
  pages={
          619-25
        }
}
Experimental studies have demonstrated that many small, single-domain proteins fold via simple two-state kinetics. We present a first principles approach for predicting these experimentally determined folding rates. Our approach is based on a nucleation-condensation folding mechanism, where the rate-limiting step is a random, diffusive search for the native tertiary topology. To estimate the rates of folding for various proteins via this mechanism, we first determine the probability of randomly… 
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Reviewing theoretical models of protein folding kinetics in terms of their ability to qualitatively rationalize this most basic of experimental observations finds that the properties known to account for variations in the folding rates of simple on- and off-lattice computational models do not account for the vast range of two-state folding rates observed in the laboratory.
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