First-phase insulin secretion: does it exist in real life? Considerations on shape and function.

  title={First-phase insulin secretion: does it exist in real life? Considerations on shape and function.},
  author={Andrea Caumo and Livio Luzi},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={287 3},
To fulfill its preeminent function of regulating glucose metabolism, insulin secretion must not only be quantitatively appropriate but also have qualitative, dynamic properties that optimize insulin action on target tissues. This review focuses on the importance of the first-phase insulin secretion to glucose metabolism and attempts to illustrate the relationships between the first-phase insulin response to an intravenous glucose challenge and the early insulin response following glucose… CONTINUE READING
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