First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses.

@article{Painter2012FirstPA,
  title={First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses.},
  author={Wendy P Painter and Alice T Robertson and Lawrence C. Trost and Susan Godkin and Bernhard M Lampert and George Painter},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 5},
  pages={2726-34}
}
CMX001 is a novel, broad-spectrum lipid antiviral conjugate (LAC) that produces high intracellular levels of the active antiviral agent cidofovir diphosphate (CDV-PP). Study CMX001-102 was a randomized, double-blind, placebo-controlled, parallel group, dose-escalating study in healthy volunteers. The objectives of the study were to evaluate the safety and pharmacokinetic parameters of CMX001 after single and multiple doses. Single doses ranging from 0.25 to 2.0 mg/kg of body weight and multiple… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

[Emerging adenovirus threats: should China develop a vaccine-oriented prevention strategy?].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] • 2014
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

KC Cundy
Antimicrob. Agents Chemother • 1995
View 4 Excerpts
Highly Influenced

Lipid conjugates of cidofovir and tenofovir, CMX001 and CMX157, are not substrates of human organic anion transporters OAT1 and OAT3, poster T3396

TK Tippin, BM Lampert, GP Painter, R. Lanier
Am. Assoc. Pharm. Sci. Annu. Meet., • 2010
View 4 Excerpts
Highly Influenced

Antiviral drug resistance of human cytomegalovirus.

Clinical microbiology reviews • 2010
View 1 Excerpt

Drug interactions and toxicities associated with the antiviral management of cytomegalovirus infection.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists • 2010
View 2 Excerpts

CMX001: anti-smallpox agent, anticytomegalovirus agent, viral polymerase inhibitor

RG Painter
Drugs Future • 2008
View 2 Excerpts

Adenovirus infections in transplant recipients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…