First-pass metabolism of midazolam by the human intestine.

  title={First-pass metabolism of midazolam by the human intestine.},
  author={Mary Paine and Danny D. Shen and Kent L. Kunze and James D. Perkins and Christopher Lee Marsh and John P. McVicar and D M Barr and B S Gillies and Kenneth E. Thummel},
  journal={Clinical pharmacology and therapeutics},
  volume={60 1},
The in vivo intestinal metabolism of the CYP3A probe midazolam to its principal metabolite, 1'-hydroxymidazolam, was investigated during surgery in 10 liver transplant recipients. After removal of the diseased liver, five subjects received 2 mg midazolam intraduodenally, and the other five received 1 mg midazolam intravenously. Simultaneous arterial and hepatic portal venous blood samples were collected during the anhepatic phase; collection of arterial samples continued after reperfusion of… CONTINUE READING


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