First-pass metabolism of ethanol is predominantly gastric.

@article{Lim1993FirstpassMO,
  title={First-pass metabolism of ethanol is predominantly gastric.},
  author={R T Lim and R. Thomas Gentry and Daisuke Ito and Hirokazu Yokoyama and Enrique Baraona and Charles S. Lieber},
  journal={Alcoholism, clinical and experimental research},
  year={1993},
  volume={17 6},
  pages={1337-44}
}
Oral consumption of alcohol results in much lower blood alcohol concentrations (BACs) than does the same dose administered intravenously, suggesting significant first-pass metabolism (FPM). The questions remain, however, (1) whether this difference truly represents FPM or simply reflects slower absorption of alcohol, and (2) if there is FPM, is it mainly of gastric or hepatic origin. To study this, rats were given the same dose alcohol (1 g/kg) by either intragastric intubation or by… CONTINUE READING
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