First-pass metabolism of decursin, a bioactive compound of Angelica gigas, in rats.

@article{Park2012FirstpassMO,
  title={First-pass metabolism of decursin, a bioactive compound of Angelica gigas, in rats.},
  author={Hyun Seo Park and Byunghyun Kim and Ju-Hee Oh and Y. Kim and Y. Lee},
  journal={Planta medica},
  year={2012},
  volume={78 9},
  pages={
          909-13
        }
}
Decursin is considered the major bioactive compound of Angelica gigas roots, a popular Oriental herb and dietary supplement. In this study, the pharmacokinetics of decursin and its active metabolite, decursinol, were evaluated after the administration of decursin in rats. The plasma concentration of decursin decreased rapidly, with an initial half-life of 0.05 h. It was not detectable at 1 h after intravenous administration at an area under the plasma concentration-time curve of 1.20 µg · mL-1… Expand
14 Citations
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References

SHOWING 1-10 OF 33 REFERENCES
The analgesic effect of decursinol
Biotransformation of plant secondary metabolite decursin by Mycobacterium sp. PYR1001.
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice
  • S. Kang, Ki Yong Lee, +4 authors Young Choong Kim
  • Medicine, Chemistry
  • Neurobiology of Learning and Memory
  • 2003
In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin.
...
1
2
3
4
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