First-pass metabolism of cyclosporin by the gut.

@article{Kolars1991FirstpassMO,
  title={First-pass metabolism of cyclosporin by the gut.},
  author={Joseph Kolars and Walid M. Awni and Robert M. Merion and Paul B Watkins},
  journal={Lancet},
  year={1991},
  volume={338 8781},
  pages={1488-90}
}
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin. 

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 97 extracted citations

Similar Papers

Loading similar papers…