First order release rate from porous PLA microspheres with limited exit holes on the exterior surface.

@article{Ehtezazi2000FirstOR,
  title={First order release rate from porous PLA microspheres with limited exit holes on the exterior surface.},
  author={Touraj Ehtezazi and Clive Washington and Colin D. Melia},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2000},
  volume={66 1},
  pages={27-38}
}
We applied the finite element method (FEM) to calculate release profiles from computer simulated slabs, one with a limited number of exit holes on the exterior surface, and the other with uniform structure. The former slab showed a first order release rate, and a nearly uniform drug concentration distribution within the device during the release process. It was concluded that circulation of the drug molecules within the slab resulted in the uniform concentration and consequently first order… CONTINUE READING