First model of spontaneous vagal hyperreactivity and its mode of genetic transmission.

  title={First model of spontaneous vagal hyperreactivity and its mode of genetic transmission.},
  author={Angelo Livolsi and Josiane Feldman and Josu{\'e} Feingold and Laurence A Weiss and Yves Alembik and Ismail M Sharifah-Anion and Michel Fischbach and Jean Messer and Pascal P Bousquet},
  volume={106 18},
BACKGROUND The main purpose of our study was to define an animal model of vagal hyperreactivity and its genetic transmission. METHODS AND RESULTS We first investigated the vagal reactivity with phenylephrine in conscious rabbits. Barosensitivity and the maximal bradycardic response were measured at the upper mean blood pressure plateau. Hyperreactive (H) animals were selected and crossbred with normal (N) ones. Results showed no significant difference between calculated barosensitivity values… CONTINUE READING

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