First life with 'alien' DNA

  title={First life with 'alien' DNA},
  author={Ewen Callaway},
  • E. Callaway
  • Published 7 May 2014
  • Engineering, Biology
  • Nature
An engineered bacterium is able to copy DNA that contains unnatural genetic letters. 
Synthetic Biology
  • I. de Lisa
  • Biology
    The Patentability of Synthetic Biology Inventions
  • 2020
The technical background necessary to understand the issues raised by the patentability of synthetic biology inventions is established and the current and futuristic research areas and their real-life applications are provided.
Nature creates, adapts, protects and sustains life using hydrogen sulfide.
Modern cells still utilize hydrogen sulfide as a signaling molecule, in pro and anti-inflammatory responses, for acquisition of tolerance against damage, in directing repair responses, as a source of energy and in modifying their genetic makeup and function to acquire a phenotype reminiscent of early life forms.


A Semi-Synthetic Organism with an Expanded Genetic Alphabet
It is shown that an exogenously expressed algal nucleotide triphosphate transporter efficiently imports the triph phosphates of both d5SICS and dNaM into Escherichia coli, and that the endogenous replication machinery uses them to accurately replicate a plasmid containing d5 SICS–dNaM.
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.
An optimized base pair is designed, d5SICS:dMMO2, which is efficiently and selectively synthesized by Kf within the context of natural DNA.
Enzymatic incorporation of a new base pair into DNA and RNA
D-iso-G was found at the correct position in the product oligonucleotide by a “nearest-neighbor” analysis9 and by the “minus” sequencing method of Sanger to determine the specificity with which the new bases pair.