First ladies in laying the foundation of neuroendocrinology

  title={First ladies in laying the foundation of neuroendocrinology},
  author={Caoimhghin S. Breathnach and John B. Moynihan},
  journal={Irish Journal of Medical Science},
Although women were welcomed into medical practice in increasing numbers by the close of the nineteenth century, it was not until the second quarter of the twentieth century that they were recognised as valuable collaborators and contributors in the nascent field of neuroendocrinology, wherein they soon made advances that have stood the test of time. Mary Pickford at Edinburgh measured the action of acetyl choline in the supraoptic nucleus of the hypothalamus and helped to establish that… 
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Lillian Mary Pickford. 14 August 1902—14 August 2002
Mary Pickford was an experimental physiologist who carried out pioneering work on the actions of the hormones (oxytocin and vasopressin [syn. antidiuretic hormone, ADH]) secreted by the posterior
Neurosecretion: A Historical Overview
The conceptual and experimental origins of neurosecretion are discussed. The discovery of the neurosecretory cell by the Scharrers and Bargmann and their insights that this cell type possessed the


Nervous Influences in Endocrine Activity
My first reaction on being asked to contribute personal reminiscences to the subject of neuroendocrinology was one of disbelief that I had ever worked in this field. I was then reminded by one of the
An experimental attempt to determine the site of the neurohypophysial and osmoreceptors in the dog
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    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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The object of this investigation has been to define the site of the osmoreceptors, a term that has been applied to those hypothetical sensory elements that respond to changes in the osmotic pressure
Neuroendocrine communication. (Neurohormonal, neurohumoral, and intermediate).
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  • Biology, Medicine
    Progress in brain research
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Multiple avenues have been acquired in the course of specialization that allow for considerable versatility in neuroendocrine mediation and the increasing familiarity with the dynamics of cellular interaction now directs attention to the exploration of biochemical events at the receptor site, which will transcend the scope of neuroendocrinology.
Stimuli that Release Hormones of the Pars Nervosa
Forty years on, it is difficult to remember and feel again accurately what it was like in those faraway days of personal ignorance when one was young, newly graduated, and beginning a career in
Neurosecretion and Its Role in Neuroendocrine Regulation
The leitmotiv of this retrospective survey is the phenomenon of neurosecretion. The gradual evolution of our current views on its place in neuroendocrinology will be discussed in terms not of one
The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs
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  • Chemistry, Medicine
    The Journal of physiology
  • 1954
The presence of noradrenaline and adrenaline in the brain has been demonstrated by von Euler and Holtz and the question whether these sympathomimetic amines, besides their role as transmitters at vasomotor endings, play a part in the function of the central nervous tissue itself is concerned.
The hypothalamo-hypophyseal system in vertebrates is in many respects similar to the intercerebralis-cardiacum-allatum system in insects.(1) In vertebrates the hypothalamic nuclei innervating the
Functional grafts of the anterior pituitary gland
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  • Biology, Medicine
    Proceedings of the Royal Society of London. Series B - Biological Sciences
  • 1952
The results offer strong support to the view that the secretion of anterior pituitary hormones is under hypothalamic control, mediated by the hypophysial portal vessels.
Regeneration of the Hypophysial Portal Vessels
It would seem established that some animals retain normal anterior pituitary function after this operation, and this fact indicates that the nerve fibres of thepituitary stalk are not involved in the link between the nervous system and the anterior pituitsary, for once cut these fibres do not regenerate.
The absorption and excretion of water by the mammal. Part I.—The relation between absorption of water and its excretion by the innervated and denervated kidney
When a large volume of water is given by mouth to the normal dog, there is usually a delay of about 10 minutes before the kidney begins to respond, and of about 50 minutes before the response reaches