First-in-human testing of a wirelessly controlled drug delivery microchip.

  title={First-in-human testing of a wirelessly controlled drug delivery microchip.},
  author={Robert Farra and Norman F Sheppard and L Mccabe and Robert M. Neer and James Michael Anderson and John T. Santini and Michael J. Cima and Robert Langer},
  journal={Science translational medicine},
  volume={4 122},
The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1-34) [hPTH(1-34)] was delivered from the device in vivo. hPTH(1-34) is the only approved anabolic osteoporosis treatment, but requires daily injections, making patient compliance an obstacle to effective treatment. Furthermore, a net increase in bone mineral density requires intermittent or pulsatile hPTH(1-34) delivery, a challenge for implantable drug delivery… CONTINUE READING
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