First-in-human testing of a wirelessly controlled drug delivery microchip.

@article{Farra2012FirstinhumanTO,
  title={First-in-human testing of a wirelessly controlled drug delivery microchip.},
  author={Robert Farra and Norman F Sheppard and L Mccabe and Robert M. Neer and James Michael Anderson and John T. Santini and Michael J. Cima and Robert Langer},
  journal={Science translational medicine},
  year={2012},
  volume={4 122},
  pages={122ra21}
}
The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1-34) [hPTH(1-34)] was delivered from the device in vivo. hPTH(1-34) is the only approved anabolic osteoporosis treatment, but requires daily injections, making patient compliance an obstacle to effective treatment. Furthermore, a net increase in bone mineral density requires intermittent or pulsatile hPTH(1-34) delivery, a challenge for implantable drug delivery… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 67 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

Microchips in Medicine: Current and Future Applications

BioMed research international • 2016
View 8 Excerpts
Highly Influenced

A Multi-site Heart Pacing Study Using Wirelessly Powered Leadless Pacemakers

2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) • 2018
View 1 Excerpt

BioMEMS for biosensors and closed-loop drug delivery.

International journal of pharmaceutics • 2018
View 2 Excerpts

Drug delivery systems for programmed and on-demand release.

Advanced drug delivery reviews • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Teriparatide therapy in a community setting: persistence and use of other osteoporosis medications in DANCE

K. Taylor, D. T. Gold, +3 authors K. Krohn
ASBMR 30th Annual Meeting: • 2008
View 9 Excerpts
Highly Influenced

Explanted pacemakers: observations of the long-term foreign body response

L. Perry, F. Karp, K.Hauch, B. D. Ratner
J. Und. Res. Bioeng • 2007
View 9 Excerpts
Highly Influenced

Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2007
View 9 Excerpts
Highly Influenced

on the Assessment of Osteoporosis at Primary Health Care Level

WHO Scientific Grou
Summary Meeting Report, Brussels, Belgium 5-7 May 2004. (WHO Press, Geneva, Switzerland, • 2007
View 9 Excerpts
Highly Influenced

Compression and cold weld sealing methods and devices

J. R. Coppeta, K. Shelton, +3 authors C.M.B. Santini
Patent App. No. 2006/0115323 • 2006
View 9 Excerpts
Highly Influenced

A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease.

The New England journal of medicine • 2004
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…